GeneSet Information

Tier III GS75742 • Celiac Disease - Genome wide association results for SNPs

DESCRIPTION:

After quality control, association analysis was performed on 310,605 SNPs with minor allele frequency >1% genotyped in 778 UK celiac cases and 1422 UK population controls

LABEL:

CelDis. SNPs

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.5

GENES IN THRESHOLD:

37

DATE ADDED:

2010-06-30

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C

TITLE:

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.

JOURNAL:

Nature genetics Jul 2007, Vol 39, pp. 827-9

ABSTRACT:

We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(-14), odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease. PUBMED: 17558408
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Annotation Information

No sequence read archive data associated with this GeneSet.


Gene Frequency (D005787)
Genetic Variation (D014644)
Chromosomes, Human, Pair 4 (D002894)
Population Control (D011155)
Linkage Disequilibrium (D015810)
Meta-Analysis (D017418)
Alleles (D000483)
Animals (D000818)
Humans (D006801)
Genome, Human (D015894)
Minors (D033242)
Mice (D051379)
Celiac Disease (D002446)
Genome-Wide Association Study (D055106)
Odds Ratio (D016017)
Genetic Predisposition to Disease (D020022)
Risk Factors (D012307)
Risk (D012306)
Interleukin-2 (D007376)
Interleukins (D007378)
HLA Antigens (D006680)
Quality Control (D011786)
Collections (D020471)
Polymorphism, Single Nucleotide (D020641)
Association (D001244)

Gene List • 37 Genes

Genes in threshold: 37

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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