DESCRIPTION:
The Lowest Association P-Value for each Phenotype Identified From the SNPs Within Each ADHD Candidate Gene. Families were collected by the International Multicenter ADHD Genetics (IMAGE) project. Families were identified through ADHD probands aged 5–17 attending outpatient clinics at the data collection sites in Europe and Israel. Patients had to meet clinical criteria for ADHD-combined type before being enrolled in the study. A total of 958 affected proband-parent trios were initially selected for the GWAS scan. Of these, 936 probands were initially ascertained as having DSM-IV combined type ADHD. Twenty-two probands who did not meet combined subtype ADHD diagnosis were included because they either met the criteria for the inattentive or hyperactive subtypes, or they missed the DSM-IV combined type diagnosis by a single item. Exclusion criteria were autism, epilepsy, IQ<70, brain disorders and any genetic or medical disorder associated with externalizing behaviors that might mimic ADHD. Six quantitative traits were generated for use in the association analyses, three from the Long Version of Conners' Parent Rating Scale (CPRS-R:L) and three from the Parental account of childhood symptom (PACS). Both the CPRS-R:L and the PACS assess the DSM-IV symptoms of ADHD in children and adolescents. The inattentive and hyperactive-impulsive symptoms included are: (1) inability to pay attention to details; (2) difficulty with sustained attention in tasks or play activities; (3) listening problems; (4) difficulty following instructions; (5) problems organizing tasks and activities; (6) avoidance or dislike of tasks that require mental effort; (7) tendency to lose things like toys, notebooks, or homework; (8) distractibility; (9) forgetfulness in daily activities; (10) fidgeting or squirming; (11) difficulty remaining seated; (12) restlessness; (13) difficulty playing quietly; (14) always seeming to be “on the go;” (15) excessive talking; (16) blurting out answers before hearing the full question; (17) difficulty waiting for a turn or in line; (18) problems with interrupting or intruding. After the quality control procedures, 438,784 markers were available for analytic use. The PBAT/FBAT programs are not compatible with sex-linked markers. Consequently, we restricted our statistical analysis to 429,981 autosomal markers. A total of 2,803 individuals, 1,865 founders and 938 non-founders were included after the cleaning process. Of these individuals, 29 offspring did not have clinical data and/or parental genotypes resulting in 909 individuals used in the analysis. We examined the association P-values of the SNPs in a set of pre-specified ADHD autosomal candidate genes that was generated by the IMAGE study investigators. These genes are as follows: ADRA1A, ADRA1B, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRBK1, ADRBK2, ARRB1, ARRB2, BDNF, CHRNA4, COMT, CSNK1E, DBH, DDC, DRD1, DRD2, DRD3, DRD4, FADS1, FADS2, HES1, HTR1B, HTR1E, HTR2A, HTR3B, NFIL3, NR4A2, PER1, PER2, PNMT, SLC18A2, SLC6A1, SLC6A2, SLC6A3 (DAT1), SLC6A4, SLC9A9, SNAP25, STX1A, STY1, TPH1, and TPH2. P-values are only presented for a gene if at least one SNP in the gene had a P-value <0.01. From Table 4.
LABEL:
Sig. SNPs from FBAT-PC all ADHD symptoms within candidate genes_pvalue
SCORE TYPE:
P-Value
THRESHOLD:
<= 0.5
GENES IN THRESHOLD:
6
DATE ADDED:
DATE UPDATED:
SPECIES:
AUTHORS:
TITLE:
JOURNAL:
ABSTRACT:
Genes in threshold: 6
| Uploaded As | Gene Symbol | Homology | Score | Priority | LinkOuts | Emphasis |
|---|
GeneWeaver