GeneSet Information

Tier IV GS408395 • Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR

DESCRIPTION:

To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.

LABEL:

Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR

SCORE TYPE:

Q-Value

THRESHOLD:

<= 0.5

GENES IN THRESHOLD:

1844

DATE ADDED:

2024-03-29

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Linda D Simmler, Allison M J Anacker, Michael H Levin, Nina M Vaswani, Paul J Gresch, Alex G Nackenoff, Noelle C Anastasio, Sonja J Stutz, Kathryn A Cunningham, Jing Wang, Bing Zhang, L Keith Henry, Adele Stewart, Jeremy Veenstra-VanderWeele, Randy D Blakely

TITLE:

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.

JOURNAL:

British journal of pharmacology Aug 2017, Vol 174, pp. 2716-2738

ABSTRACT:

The psychostimulant cocaine induces complex molecular, cellular and behavioural responses as a consequence of inhibiting presynaptic dopamine, noradrenaline and 5-HT transporters. To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. PUBMED: 28585320
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Annotation Information

No sequence read archive data associated with this GeneSet.


Clinical Coding (D059019)
Synaptosomes (D013574)
Dopamine (D004298)
Microdialysis (D017551)
Cocaine (D003042)
abnormal cocaine consumption (MP:0002556)
sensitization (GO:0046960)
synaptosome (GO:0019717)
Prediction, detection and recognition (EDAM_operation:2423)
CPP (CHEBI:34603)
(R)-noradrenaline (CHEBI:18357)
Fluthiacet methyl (CHEBI:5133)
cocaine (CHEBI:27958)
cocaine(1+) (CHEBI:60056)
serotonin (CHEBI:28790)
dopamine (CHEBI:18243)
dopaminium(1+) (CHEBI:59905)
noradrenaline (CHEBI:33569)
Acute (HP:0011009)
Chronic (HP:0011010)
import across plasma membrane (GO:0098739)
conditioned place preference (GO:1990708)
import into cell (GO:0098657)

Gene List • 13047 Genes

Genes in threshold: 1844

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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