DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Exhaled carbon monoxide levels. The EFO term smoking behavior, carbon monoxide exhalation measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: smoking behavior, carbon monoxide exhalation measurement

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

AJ Bloom, SM Hartz, TB Baker, LS Chen, ME Piper, L Fox, M Martinez, D Hatsukami, EO Johnson, CC Laurie, NL Saccone, A Goate, LJ Bierut

TITLE:

Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide.

JOURNAL:

Annals of the American Thoracic Society Sep 2014, Vol 11, pp. 1003-10

ABSTRACT:

The CHRNA5-CHRNA3-CHRNB4 locus is associated with self-reported smoking behavior and also harbors the strongest genetic associations with chronic obstructive pulmonary disease (COPD) and lung cancer. Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking. PUBMED: 25072098
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