DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Smoking behavior. The EFO term smoking behavior was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: smoking behavior

SCORE TYPE:

P-Value

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

JZ Liu, F Tozzi, DM Waterworth, SG Pillai, P Muglia, L Middleton, W Berrettini, CW Knouff, X Yuan, G Waeber, P Vollenweider, M Preisig, NJ Wareham, JH Zhao, RJ Loos, I Barroso, KT Khaw, S Grundy, P Barter, R Mahley, A Kesaniemi, R McPherson, JB Vincent, J Strauss, JL Kennedy, A Farmer, P McGuffin, R Day, K Matthews, P Bakke, A Gulsvik, S Lucae, M Ising, T Brueckl, S Horstmann, HE Wichmann, R Rawal, N Dahmen, C Lamina, O Polasek, L Zgaga, J Huffman, S Campbell, J Kooner, JC Chambers, MS Burnett, JM Devaney, AD Pichard, KM Kent, L Satler, JM Lindsay, R Waksman, S Epstein, JF Wilson, SH Wild, H Campbell, V Vitart, MP Reilly, M Li, L Qu, R Wilensky, W Matthai, HH Hakonarson, DJ Rader, A Franke, M Wittig, A Schäfer, M Uda, A Terracciano, X Xiao, F Busonero, P Scheet, D Schlessinger, D St Clair, D Rujescu, GR Abecasis, HJ Grabe, A Teumer, H Völzke, A Petersmann, U John, I Rudan, C Hayward, AF Wright, I Kolcic, BJ Wright, JR Thompson, AJ Balmforth, AS Hall, NJ Samani, CA Anderson, T Ahmad, CG Mathew, M Parkes, J Satsangi, M Caulfield, PB Munroe, M Farrall, A Dominiczak, J Worthington, W Thomson, S Eyre, A Barton, V Mooser, C Francks, J Marchini

TITLE:

Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

JOURNAL:

Nature genetics May 2010, Vol 42, pp. 436-40

ABSTRACT:

Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3. PUBMED: 20418889
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