DESCRIPTION:

List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was QT interval. The EFO term QT interval was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.

LABEL:

GWAS: QT interval

SCORE TYPE:

P-Value

THRESHOLD:

<= 0.05

GENES IN THRESHOLD:

30

DATE ADDED:

2017-05-02

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

JG Smith, CL Avery, DS Evans, MA Nalls, YA Meng, EN Smith, C Palmer, T Tanaka, R Mehra, AM Butler, T Young, SG Buxbaum, KF Kerr, GS Berenson, RB Schnabel, G Li, PT Ellinor, JW Magnani, W Chen, JC Bis, JD Curb, WC Hsueh, JI Rotter, Y Liu, AB Newman, MC Limacher, KE North, AP Reiner, PM Quibrera, NJ Schork, AB Singleton, BM Psaty, EZ Soliman, AJ Solomon, SR Srinivasan, A Alonso, R Wallace, S Redline, ZM Zhang, WS Post, AB Zonderman, HA Taylor, SS Murray, L Ferrucci, DE Arking, MK Evans, ER Fox, N Sotoodehnia, SR Heckbert, EA Whitsel, C Newton-Cheh

TITLE:

Impact of ancestry and common genetic variants on QT interval in African Americans.

JOURNAL:

Circulation. Cardiovascular genetics Dec 2012, Vol 5, pp. 647-55

ABSTRACT:

Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. PUBMED: 23166209
Find other GeneSets from this publication