Fly Aging Genes that have been studied with respect to their effects on life-span or age-related neurological diseases SAGE KE Database and result in correlation, increase or decrease.
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "biological_process", which is defined as "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to extracellular stimulus", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "determination of adult lifespan", which is defined as "The control of viability and duration in the adult phase of the life-cycle." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "aging", which is defined as "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to starvation", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "multicellular organism development", which is defined as "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to external stimulus", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to stress", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to nutrient levels", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "developmental process", which is defined as "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "multicellular organismal process", which is defined as "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "multicellular organism aging", which is defined as "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "anatomical structure development", which is defined as "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "response to stimulus", which is defined as "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
561 differentially expressed genes in Cluster 24 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
548 differentially expressed genes in Cluster 27 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
512 differentially expressed genes in Cluster 29 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
472 differentially expressed genes in Cluster 33 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S6. From table legend: "This analysis was performed (per cluster) without separating male and female samples. Entries that are greyed out have p_val_adj < 0.05. “Avg_diff” is conditionally formatted to indicate up- and down-regulation of expression in cocaine compared to sucrose (red: up-regulated, green: down-regulated and yellow: no difference). The “Names” sheet at the end of file was used to convert GeneIDs to FlybaseIDs and Gene Symbols. p_val: raw p-value from the differential expression analysis for the given gene in the corresponding cluster. avg_diff: the difference in the loge transformed average expression of the given gene in the corresponding cluster (sheet) between the two conditions (cocaine compared to sucrose). Values above 0 indicate up-regulation of expression due to cocaine, and likewise, values below zero represent downregulation of expression due to cocaine. pct.1: percentage of cells expressing the gene in the cluster from the first condition (cocaine). pct.2: percentage of cells expressing the gene in the cluster from the second condition (sucrose). p_val_adj: Benjamini-Hochberg FDR adjusted p-value." Values presented are p-adjusted values. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
551 differentially expressed genes in Cluster 0 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S7. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
552 differentially expressed genes in Cluster 1 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S7. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
484 differentially expressed genes in Cluster 11 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S7. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
567 differentially expressed genes in Cluster 17 in the Canton S (B) fruit fly following cocaine administration. Gene expression was measured via sequencing using an S1 flow cell with a NovaSeq Data taken from Supplemental Table S7. Data available at GEO with accession number GSE152495.
Authors:
Brandon M Baker, Sneha S Mokashi, Vijay Shankar, Jeffrey S Hatfield, Rachel C Hannah, Trudy F C Mackay, Robert R H Anholt
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